Diabetes

Lock and Key

Glucose - our primary fuel - can't simply be used as fuel. Our cells are locked and first need a key that allows glucose from the blood into the cells. This key is insulin, a hormone produced by the pancreas.

Type I diabetes = an autoimmune disease.

With Type I, insulin is no longer produced. The cells that produce insulin—the pancreatic β-cells—are mistakenly recognized by the body as harmful, intruders, and are destroyed. Without insulin, glucose accumulates in the blood, damaging blood vessels. This disease can lead to blindness, kidney failure, and heart failure. The nervous system can also be damaged. This combination can lead to poor blood circulation and loss of sensation in limbs, poor wound healing, and sometimes amputation.

The medical term for excess glucose in the blood is hyperglycemia. Over time, cells begin to break down fats for energy. This produces ketones, which acidify the body and can be dangerous.

Type I symptoms: fatigue, frequent urination, weight loss, dry tongue, excessive drinking, decreased appetite.

Causes of Type I Diabetes

The exact cause is unknown, but there is growing evidence that a genetic predisposition combined with exposure to viral infections and/or cow's milk plays a role.

In 1992, a report appeared in the New England Journal of Medicine following a study on the presence of antibodies in children who were bottle-fed (cow's milk) instead of breastfed. The antibodies against milk proteins attack the pancreas and destroy the β-cells. See also the section on autoimmune diseases.

Milk Consumption Is Linked to Type 1 Diabetes

Written By Michael Greger M.D. FACLM on November 26th, 2019

https://nutritionfacts.org/2019/11/26/milk-consumption-is-linked-to-type-1-diabetes/

Lempainen J, Tauriainen S, Vaarala O, Mäkelä M, Honkanen H, Marttila J, Veijola R, Simell O, Hyöty H, Knip M, Ilonen J. Interaction of enterovirus infection and cow's milk-based formula nutrition in type 1 diabetes-associated autoimmunity. Diabetes Metab Res Rev. 2012 Feb;28(2):177-85.

Karjalainen J, Martin JM, Knip M, Ilonen J, Robinson BH, Savilahti E, Akerblom HK, Dosch HM A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus. N Engl J Med. 1992 Jul 30;327(5):302-7.

Greger, M., Stone, G. How not to die. MacMillan 2016; p. 102.

M Roden, T B Price, G Perseghin, K F Petersen, D L Rothman, G W Cline, and G I Shulman Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest. 1996 Jun 15; 97(12): 2859–2865.

Obesitasvereniging.nl 2018

Type II Diabetes = a lifestyle disease.

With Type II diabetes, insulin is still produced, but the cell receptors can't use it effectively; this is called resistance. This resistance is caused by fat. Fat prevents the receptors in our body cells from absorbing sugar. If insulin is the key to allowing sugar into our cells, then fat is the chewing gum on the lock. This is intramyocellular fat—the fat in muscle cells where it can form toxic waste products and free radicals, both of which hinder insulin's function. The muscle cells are, as it were, "compromised" by the fat present.

Moreover, excess fat can escape the cells and reenter the bloodstream, which in turn prevents insulin from binding to the muscle cells' receptors, preventing them from absorbing glucose.

Causes of Type II diabetes

Type II diabetes is primarily a consequence of poor diet choices; the more fat, the greater the risk of diabetes Type II.

Fat the culprit? Yes...

Why such an explosion of obesity… worldwide?

It's really not about the amount on your plate and lack of exercise. There's another factor at play: chemical pollutants that disrupt our metabolism and make us more susceptible to obesity. In 95% of cases, these chemical pollutants are found in animal fat. And the more chemical pollutants in the blood, the higher the risk of diabetes. The chemical compound hexachlorobenzene—found in sardines and salmon, for example—is a particular risk factor. And where do these polluting chemical elements like to nest? In our fat.

Not all fats affect insulin resistance in the same way. Palmitate, a saturated fat—found primarily in meat, dairy, and eggs—causes insulin resistance. Oleates, on the other hand, monounsaturated fats—found in nuts, olives, and avocados—protect us from the disastrous effects of saturated fats.

Saturated fats bring all sorts of problems, such as the accumulation of toxic breakdown products, the formation of free radicals, inflammation, and even dysfunction in mitochondria (our power plants!); in other words: lipotoxicity.

Symptoms of Type II Diabetes: fatigue, frequent urination, thirst, eye problems

https://www.nu.nl/gezondheid/5457971/bijna-helft-van-alle-nederlanders-zwaar.html 12 september 2018

Magliano DJ1, Loh VH2, Harding JL3, Botton J4, Shaw JE3. Persistent organic pollutants and diabetes: a review of the epidemiological evidence. Diabetes Metab. 2014 Feb;40(1):1-14. doi: 10.1016/j.diabet.2013.09.006. Epub 2013 Nov 18.

Lee DH, Lee IK, Song K, Steffes M, Toscano W, Baker BA, Jacobs DR Jr. A strong dose-response relation between serum concentrations of persistent organic pollutants and diabetes: results from the National Health and Examination Survey 1999-2002. Diabetes Care. 2006 Jul;29(7):1638-44.

Nolan CJ, Larter CZ. Lipotoxicity: why do saturated fatty acids cause and monounsaturates protect against it? J Gastroenterol Hepatol. 2009 May;24(5):703-6. doi: 10.1111/j.1440-1746.2009.05823.x.

Egnatchik RA, Leamy AK, Jacobson DA, Shiota M, Young JD. ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to palmitate overload. Mol Metab. 2014 May 22;3(5):544-53. doi: 10.1016/j.molmet.2014.05.004. eCollection 2014 Aug.

Yet, billions are being spent on medication.

Continuing to supplement people suffering from diabetes Type II with insulin has very adverse side effects (including inflammation and narrowing of arteries) and doesn't address the underlying cause.

This is like having bypass surgery because your arteries are clogged by plaque buildup due to excessive cholesterol intake. The bypass will also become clogged if you don't adjust your diet!

Type II diabetes is completely preventable, treatable, and reverseable through diet.

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